Category: Publications

Apr 10

Ability To Develop Broadly Neutralizing HIV-1 Antibodies…

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Ability To Develop Broadly Neutralizing HIV-1 Antibodies Is Not Restricted by the Germline Ig Gene Repertoire This work is part of our ongoing collaboration with CAPRISA and shows that there is no difference in the germline IGHV repertoires between individuals who do and do not develop broadly neutralizing antibodies.  This is significant because it suggests that …

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May 28

RAMICS: fast high-throughput sequence alignment

RAMICS HMM

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RAMICS is a method developed at SANBI that undertakes fast and highly accurate mapping/alignment of coding sequence reads in a biologically relevant manner.  It identifies, and accounts for, PCR and sequencing induced errors resulting in an alignment that maintains the correct reading frame thereby enabling SNPs to be distinguished from noise. The challenge presented by …

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