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Tsetse (glossina) is the vector for trypanosomes, which cause, among other diseases, human African trypanosomiasis (HAT). There are more than 300,000 cases of HAT with millions more people at risk in 37 countries in Africa. Although not present in South Africa, HAT is prevalent in neighboring countries and with new cases being reported in countries such as Zimbabwe, Zambia and Mozambique to name but a few.

Vaccines are not available and drug treatment relies on old, often dangerous drugs and resistance is becoming an increasing problem. Insights into the interaction of the trypanosome and the host could promote improved intervention strategies.

Collaborators: IGGI consortium including Mat Berriman – Sanger Centre; Serap Aksoy – Yale; Dan Masiga – International Centre for Insect Physiology and Entymology, Kenya; Mike Lehane – Liverpool tropical school of Medicine

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