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Tiffin group – Published papers

Wright GEB, Koornhof PGJ, Adeyemo AA, Tiffin N. Ethical and legal implications of whole genome and whole exome sequencing in African populations. BMC Med Ethics. 14:21. 2013. (Link to Wright et al. 2013).

Tiffin N, Adeyemo A, Okpechi I. A diverse array of genetic factors contribute to the pathogenesis of Systemic Lupus Erythematosus. 2013. Orphanet J Rare Dis. 2013 Jan 7;8(1):2. (Link to Tiffin et al. 2013).

Rabhi I, Rabhi S, Ben-Othman R, Rasche A, The Sysco Consortium*, Daskalaki A, Trentin B, Piquemal D, Regnault B, Descoteaux A, Guizani-Tabbane L. Transcriptomic signature of Leishmania infected mice macrophages: a metabolic point of view. PLoS Negl Trop Dis. 2012 Aug;6(8):e1763 (Link to Rabhi et al. 2012) * includes Nicki Tiffin

Okpechi I, Swanepoel CR, Tiffin N, Duffield M, Rayner B. Clinicopathological insights into lupus nephritis in South Africans: A study of 251 patients. Lupus 2012, March 26, 2012.(Link to Okpechi, I et al. Lupus 2012).

Tiffin, N. Book Chapter: Methods in Molecular Biology: In Silico Tools for Gene Discovery. Chapter title: Conceptual thinking for prioritization of candidate disease genes.Methods Mol Biol. 2011;760:175-87. (Link to: Tiffin, N. 2011).

Tiffin N, Meintjes A, Ramesar R, Bajic VB, Rayner B. Computational Analysis of Candidate Disease Genes and Variants for Salt-Sensitive Hypertension in Indigenous Southern Africans. PLoS ONE 2010 5(9): e12989. doi:10.137 /journal.pone.0012989 (Link to: Tiffin et al. PLoSONE 2010 ).

Okpechi I, Rayner BL, van der Merwe L, Mayosi BM, Adebowale A, Tiffin N, Ramesar R. Genetic variation at selected SNPs in the Leptin gene and association of alleles with markers of kidney disease in a Xhosa population of South Africa. PLoS ONE 5(2): e9086. doi:10.1371/journal.pone.0009086 (Link to: Okpechi et al. 2010).

Tiffin N, Andrade-Navarro M A, Perez-Iratxeta C. Linking genes to diseases: it’s all in the data. Genome Medicine 2009, 1:77 (Link to: Tiffin et al.2009, Genome Medicine) (Highly Accessed).

Tiffin N, Okpechi I, Perez-Iratxeta C, Andrade-Navarro MA, Ramesar R. Prioritisation of candidate disease genes for metabolic syndrome by computational analysis of its defining phenotypes. Physiol Genomics. 2008 Jul 8. (Link to: Tiffin et al. 2008, Physiological Genomics).

Yamasaki C, Murakami K, Fujii Y, Sato Y, Harada E et al. 2008. Genome Information Integration Project and H-Invitational 2 Consortium* (2008) The H-Invitational Database (H-InvDB), a comprehensive annotation resource for human genes and transcripts. Nucleic Acids Research. 2008 January; 36 (Database issue): D793–D799 (Link to: Yamasaki et al. 2007, Nucleic Acids Research).

Lombard Z, Tiffin N, Hofmann O, Bajic VB, Hide W, Ramsay M. 2007. Computational selection and prioritization of candidate genes for Fetal Alcohol Syndrome. BMC Genomics. 2007 Oct 25;8(1):389 (Link to: Lombard et al. 2007, BMC Genomics).

Dias da Silva, M.R., Tiffin N., Mima T., Mikawa, T. Hyer, J.D. 2007. FGF-mediated induction of ciliary body tissue in the chick eye. Developmental Biology, available online 21 December 2006. (Link to:Hyer et al. 2007, Developmental Biology).

Tiffin N., Adie E., Turner F., Brunner H.G., van Driel M.A., Oti M., Lopez-Bigas N., Ouzonis C., Perez-Iratxeta C., Andrade M.A., Adeyemo A., Patti M.E., Semple C.A.M., Hide W. 2005. Computational disease gene identification: a concert of methods prioritises type 2 diabetes and obesity candidate genes. Nucleic Acids Research 2006 34(10):3067-3081. (Link to: Tiffin et al. 2006, Nucleic Acids Research).

Tiffin, N., Kelso, J.F., Powell, A.R., Pan, H., Bajic, V.B., Hide, W.A. 2005. Integration of text- and data-mining using ontologies successfully selects disease gene candidates. Nucleic Acids Research 33 (5): 1544 – 1552. (Link to: Tiffin et al. 2005. Nucleic Acids Research).

This paper has been additionally selected for publication in the AMA 2006 IMIA Yearbook of Medical Informatics, in Section 7: Bioinformatics/Best Paper Selection (Link to: IMIA Yearbook of Medical Informatics, Bioinformatics Best Paper Selection 2006).

Tiffin, N., Adi, S., Stokoe, D., Wu, N.Y., and Rosenthal, S.M. Akt phosphorylation is not sufficient for insulin-like growth factor-stimulated myogenin expression but must be accompanied by down-regulation of mitogen-activated protein kinase/extracellular signal-regulated kinase phosphorylation. Endocrinology 145: 4991-4996. 2004 (Link to Tiffin et al, Endocrinology).

Tiffin N, WilliamsR D, Robertson D, HillS, ShipleyJ, Pritchard-JonesK : WT1 expression does not disrupt myogenic differentiation in C2C12 murine myoblasts or in human rhabdomyosarcoma. Experimental Cell Research, July 1;287(1):155-65. 2003TiffinN, WilliamsR D, ShipleyJ, Pritchard-Jones, K: PAX7 expression in embryonal rhabdomyosarcoma suggests an origin in muscle satellite cells. British Journal of Cancer, July 21;89(2):327-332. 2003. (Link to Tiffin et al BJC).

Lu Y-J, Williamson D, Clark J, Wang R, Tiffin N, Skelton L, Gordon T, Williams R, Allan B, Jackman A, Cooper C, Pritchard-Jones K, Shipley J.: Comparative expressed sequence hybridization to chromosomes for tumor classification and identification of genomic regions of differential gene expression. PNAS 98(16):9197-9202, 2001. (Link to Lu et al PNAS).

Cocker HA, Tiffin N, Pritchard-Jones K, Ross Pinkerton C, Kelland LR: In vitro prevention of the emergence of multidrug resistance in a pediatric rhabdomyosarcoma cell line. Clin Can Res 7:3193-3198, 2001. (Link to Cocker et al CCR).

Cocker HA, Hobbs SM, Tiffin N, Pritchard-Jones K, Pinkerton CR, Kelland LR: High levels of the MDM2 Oncogene in paediatric rhabdomyosarcoma cell lines may confer multidrug resistance. British Journal of Cancer 85(11), 1746-1752, 2001. (Link to Cocker et al BJC).