Home » People » Faculty » External and Adjunct Professors » Cathal Seoighe

Cathal Seoighe

• Name: Cathal Seoighe
• Role: Adjunct Professor

• Contact Details
  • Telephone: +27 21 406 6837
  • Mobile:
  • Email: cathal ‘-a-’ science.uct.ac.za

• Research Area:
• Development of novel methods to detect selection
• Allelic differences in gene expression and mRNA splicing
• Co-evolution of genome organisation and gene

• Lab Members:

Selected Publications

Seoighe C, Nembaware V, Scheffler K Maximum likelihood inference of imprinting and allele-specific expression from EST data
Bioinformatics 2006, Oct 11

Scheffler K, Martin DP, Seoighe C Robust inference of positive selection from recombining coding sequences
Bioinformatics. 2006 Oct 15;22(20):2493-9

Scheffler K, Seoighe C. (2005) A bayesian model comparison approach to inferring positive selection.
Molecular Biology & Evolution. 2005 Dec;22(12):2531-40.

Seoighe C., Scheffler, K. (2005) Low power to detect asymmetric divergence of duplicated genes
In Proceedings of the RECOMB 2005 International Workshop on Comparative Genomics Eds McLysaght, A. & Huson D.H.

Seoighe C, Gehring C, Hurst LD. (2005) Gametophytic Selection in Arabidopsis thaliana Supports the Selective Model of Intron Length Reduction.
PLoS Genet. 2005 Aug 5;1(2):e13

Nembaware V, Wolfe KH, Bettoni F, Kelso J, Seoighe C. Allele-specific transcript isoforms in human.
FEBS Lett. 2004 Nov 5;577(1-2):233-8.

Seoighe, C., Gehring, C. Genome duplication led to highly selective expansion of the Arabidopsis thaliana proteome
Trends in Genetics 2004 Oct;20(10):461-4.

Swart, E.C. , Hide, W.H., Seoighe, C. FRAGS: estimation of coding sequence substitution rates from fragmentary data
BMC Bioinformatics, 2004 Jan 29;5(1):8.

Seoighe, C. Turning the clock back on ancient genome duplication
Curr Opin Genet Dev. 2003 Dec;13(6):636-43.

Seoighe, C. Johnston, C.R. Shields, D.C. Significantly different patterns of amino acid replacement after gene duplication as compared to after speciation
Mol Biol Evol. 2003 Apr;20(4):484-90.

Nembaware, V. Crum, K. Kelso, JF, Seoighe, C. Impact of the presence of paralogues on sequence divergence in a set of mouse-human orthologues
Genome Res. 2002 Sep;12(9):1370-6.

Hide WA, Babenko VN, van Heusden PA, Seoighe C, Kelso JF. The contribution of exon-skipping events on chromosome 22 to protein coding diversity.
Genome Res. 2001 Nov;11(11):1848-53.

Seoighe C, Federspiel N, Jones T, Hansen N, Bivolarovic V, Surzycki R, Tamse R, Komp C, Huizar L, Davis RW, Scherer S, Tait E, Shaw DJ, Harris D, Murphy L, Oliver K, Taylor K, Rajandream MA, Barrell BG, Wolfe KH. (2000) Prevalence of small inversions in yeast gene order evolution.
Proc Natl Acad Sci U S A. Nov 21

Research Interests

My research interests are in a range of different areas within computational molecular evolution including the development and application of methods of inferring evolutionary adaptation from coding and non-coding molecular sequences, with application to viruses and other systems. Impact of immune surveillance on HIV sequence evolution, viral escape from cytotoxic immune responses and implications for vaccine design. Investigation and quantification of allele-specific mRNA splicing and allelic differences in gene expression in mammals. Development of probabalistic models for gene expression data to infer allelic differences in gene expression caused by imprinting and loss of heterozygosity in cancer. Evolution following gene duplication including the impact of gene duplication on evolutionary rates.

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