IGGI proposal

The International Glossina Genomics Initiative (IGGI) has been established to develop genomic resources for the insect vector of African Trypanosomiasis. Genomic resources are now in production, with several million pounds committed for genome sequencing, assembly and basic annotation by the Wellcome Trust. But post-genomic resources to exploit the genome and translate its content into more effective vector control projects have not yet been developed. The problem of effective, targeted resource exploitation therefore urgently needs to be addressed. Not only does the term “Genome resources” refer to the genome sequence, but it also includes key resources such ESTs, full- length mRNAs, plasmids, microsatellite and array clones. These and other resources combine in complex ways with genome data and play additive roles in applying molecular information to develop appropriate control measures. In order to ensure the successful utilization of these genomic resources for vector control it is essential that human resources be developed and dedicated to translational genomic efforts such as targeted insecticide development, population genetic and control studies, host-seeking studies leading to improved trap and target design, and indirect transgenic approaches via symbionts. Information resource development and community building is therefore key to the success of post-genomic efforts to perform strategic vector control and implementation. IGGI is especially aiming to increase the size and impact of the Glossina research community and is promoting training and capacity building in disease endemic countries. Given the aims and scope of IGGI it is essential that a research tool is developed to ensure delivery of value for genome resources, and is implemented in such a manner so as to promote the development of the vector control and research community.