Research Laboratory of Hocine Bendou
Contact Details
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- Email: hocine(at)sanbi.ac.za
Highlights of the lab - 2019
Student supervision:
Abdulazeez Giwa – PhD, SANBI
Nasr Eshibona – PhD, SANBI
Wardah Jassiem – MSc, SANBI
Nomlindelo Mfuphi – MSc, SANBI
Victoria Patten – PhD, UCT
Grants application
NIH grant on Diffuse Large B-Cell Lymphoma.
Self-initiated research SAMRC grant on pancreatic adenocarcenoma.
Research Projects
As a new research group, our interests lie in the area of genomics focusing on identification of genetic abnormalities driving the genesis and progression of human cancer, using bioinformatics. The group is working on developing bioinformatics pipelines, and applying RNA-Seq and Whole Genome Sequencing (WGS) methods in analysing different
types of cancer including; Neuroblastoma, Acute Myloid Leukemia and Diffuse Large B-Cell Lymphoma.
The group works with external collaborators to identify the role of integrated viral DNA in oesophageal cancer by using WGS combined with ERVCaller tool.
Research Collaborations
Differential Expression Protein On Unexplained Male Infertility
Collaborating Parties:
Prof Ashok Agarwal – American Center for
Reproductive Medicine, Cleveland Clinic,
Cleveland
Dr Hocine Bendou – SANBI, UWC
Nature and purpose:
Provide bioinformatics and statistics expertise.
Output in the last 12 months:
Sperm Proteome analysis and identification of
fertility-associated biomarkers in unexplained
male infertility.
Molecular Biology and Genetics of Oesophageal Cancer
Collaborating Parties:
Prof Iqbal Parker – UCT
Dr Hocine Bendou – SANBI, UWC
Nature and purpose:
Provide bioinformatics expertise and PhD student co-supervision.
Output in the last 12 months:
Ongoing work on viral DNA integrated in human oesophageal cancer.
Future Direction:
Whole genome sequencing analysis on paired tumor-normal samples from 60 participants.
Prepare and publish a manuscript.